36 Deliverables submitted

– Literature review reports on the different carrier systems as well as topical and pulmonary delivery systems

– Choice and synthesis of AMPs to be included in the project

In vitro biofilm models (Cystic fibrosis and burn wound infections)

– Ethical applications for in vivo studies

– Reports related to the development of different nanocarriers (lipidbased, polymerbased and mesoporous silica nanoparticles) for AMPs

– Report summarizing the results from the first and second round of effect studies on the nanoformulated AMPs as well as ex vivo results on safety and effect

–  Cross-validation of methods, sample handling etc. between labs

– FORMAMP webpage

– Plan for collaboration between NMP-AMR cluster Projects

– Course plan-Regulathory education

– Interim report M6, M12, M24, M30

 

Ongoing activities

In vitro evaluation of nanoformulated AMPs- to understand mechanism of action

– Loading and release of AMPs in nanoformulations-optimization and elucidate interaction between peptides and carriers

– Formulation of delivery systems for local administration on skin (gels, creams) and lung (aerosols or powders for inhalation)

Ex vivo evaluation of formulations- antimicrobial effect on infected skin, toxicity of nanocarriers after inhalation

– Stability studies- systematic studies to investigate the for chemical, physical and proteolytic stability of peptides in formulations

In vivo evaluation of effect and safety